When world-renowned Harvard symbologist Robert Langdon is summoned to a Swiss research facility to analyze a mysterious symbol, he discovers evidence of the unimaginable: the resurgence of an ancient and powerful secret brotherhood known as the Illuminati—which has its sights on its longtime enemy: the Catholic Church.

Desperate to save the Vatican, Langdon joins forces in Rome with the beautiful and mysterious scientist Vittoria Vetra. Together, they embark on a frantic hunt through sealed crypts, dangerous catacombs, deserted cathedrals, and the most secretive vault on earth—the long-forgotten Illuminati lair which houses the only hope for the salvation of the Catholic Church.